Table 2. Biochemical data for healthy controls and patients with mild primary hyperparathyroidism before and after parathyroidectomy.
| Variable | Controls | PHPT | PHPT Baseline | ||
| Baseline | Follow-up | vs. Controls | vs. Follow-up | ||
| n = 48 (35 F) | n = 48 (35 F) | n = 48 (35 F) | p-value | p-value | |
| P-PTH (10–65 ng/L) | 44.0±12.5 | 120.0±40.4 | 49.6±15.7 | <0.001 | <0.001 |
| P-Calcium (2.15–2.50 mmol/L) | 2.29±0.08 | 2.61±0.12 | 2.27±0.08 | <0.001 | <0.001 |
| S-Ca++ (1.15–1.33 mmol/L) | 1.25±0.04 | 1.46±0.06 | 1.25±0.05 | <0.001 | <0.001 |
| P-Phosphate (0.80–1.5 mmol/L) | 1.06±0.17 | 0.85±0.16 | 1.01±0.17a | <0.001 | <0.001 |
| Ca*Phosphate | 2.43±0.41 | 2.20±0.39 | 2.32±0.40 | <0.01 | 0.050 |
| S-25-OH-D (75–250 nmol/L) | 64.1±20.6b | 40.6±17.1a | 58.2±19.5 | <0.001 | <0.001 |
| P-Creatinine (<90 µmol/L) | 69.1±13.6 | 66.3±12.1a | 68.1±15.9b | 0.434 | 0.386 |
| GFR, mL/min (>90 mL/min) | 93.0±22.0 | 100.9±22.2a | 103.1±27.7b | 0.049 | 0.861 |
| P-Glucose (4.0–6.0 mmol/L) | 5.0±0.34a | 5.0±0.46b | 4.9±0.52a | 0.523 | 0.471 |
| P-hs-CRP (<3 mg/L) | 1.14±1.22b | 0.92±0.90a | 1.95±5.05c | 0.553 | 0.004 |
| S-Cholesterol (3.9–7.8 mmol/L) | 5.71±1.03b | 5.74±0.80a | 5.85±0.89 | 0.857 | 0.163 |
| S-TG (0.45–2.6 mmol/L) | 0.86±0.43b | 1.00±0.54a | 0.93±0.51 | 0.073 | 0.045 |
| S-Apo-A1 (1.10–2.10 g/L) | 1.73±0.32b | 1.72±0.32a | 1.69±0.28 | 0.786 | 0.760 |
| S-Apo-B (0.50–1.70 g/L) | 1.02±0.21 | 1.01±0.18a | 1.06±0.17 | 0.954 | 0.003 |
| Apo B/Apo-A1 (<1) | 0.60±0.14b | 0.61±0.17a | 0.64±0.13 | 0.997 | 0.117 |
| P-VWF (0.60–1.60 kIE/L) | 1.11±0.40b | 1.05±0.36b | 1.07±0.40b | 0.467 | 0.647 |
| P-PAI-1 (<15 kIE/L) | 10.07±6.90b | 9.51±7.73b | 8.69±7.49b | 0.320 | 0.661 |
| P-Homocysteine (5.0–15.0 µg/L) | 9.30±3.00b | 9.87±2.75a | 9.59±2.29a | 0.295 | 0.266 |
| S-IGF-1 (110–270 µg/L) | 137.5±52.9b | 146.2±48.3a | 143.6±68.2 | 0.323 | 0.086 |
a
n = 47,
b
n = 44–46.
c
One patient had CRP 35.40 mg/L at follow-up, after excluding the patient, mean hs-CRP was 1.26±1.09 mg/L, p<0.01. Values are shown as means±SD. F = female, P = plasma, S = serum, PTH = parathyroid hormone, S-Ca++ = ionised calcium, S-25-OH-D = 25 hydroxyvitamin D, GFR = glomerular filtration rate. P-hsCRP = high sensitivity C-reactive protein, TG = triglycerides, Apo = apolipoprotein, VWF = von Willebrand factor antigen, PAI-1 = plasminogen activator inhibitor-1 activity, IGF-1 = insulin like growth factor.