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. 2012 Jul 16;7(7):e40085. doi: 10.1371/journal.pone.0040085

Figure 5. Inter-trajectory distance, profile of specific input combinations and typical switching dynamics.

Figure 5

(A) Time-dependent profile for each input Inline graphic for 3 input combinations: Inline graphic, Inline graphic, Inline graphic. (B) Inter-trajectory distance for pairs Inline graphic inducing the same attractors (see Fig. 4A). Pairs exhibiting the highest value for Inline graphic (Eq. (4)) and the lowest value for Inline graphic. Inset: zoom of Inline graphic curve for Inline graphic. (C) Typical evolution of concentrations for all the nodes Inline graphic, Inline graphic. This particular trajectory was generated by applying Inline graphic and noise intensity Inline graphic (see Methods). (D) Amplification of (C) for early times t. (E) Amplification of (C) for concentrations Inline graphic close to zero. Inline graphic, i.e. the concentration of each transcription factor is represented here by Inline graphic and associated with Inline graphic in Eqs. (7) and (8) with Inline graphic (see Methods). Parameters: Inline graphic, Inline graphic, Inline graphic, Inline graphic (self-activation) and Inline graphic (cross-repression), Inline graphic (see Methods), for Inline graphic.