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. 2012 Jul 16;7(7):e40522. doi: 10.1371/journal.pone.0040522

Figure 2. DRiP78 interaction with CCR5 homodimers.

Figure 2

a) CXCR4 and CCR5 sequences corresponding to the potential interaction site of DRiP78, starting at the beginning of the carboxy-terminal tail of the receptor. b) Co-immunoprecipitation of DRiP78 with CCR5 WT or with a mutation of the potential interaction site (phenylalanine residues mutated to alanine residues) and with CXCR4-v1/CCR5-v2. c) Interaction of CXCR4 with DRiP78. d) CCR5 c-tail interaction with DRiP78. The GST-CCR5 c-tails (wild type or F/A mutant) were incubated HEK293A cell lysates expressing DRiP78 to detect the interaction.