Figure 8. GPR26^−/− mice exhibit hypersensitivity to CB1 antagonist.

After 12-weeks of high-fat diet, GPR26 knockout mice (KO) and wild type littermates (WT) were administrated daily by oral gavage with 10 mg of rimonabant (SR141716A ), an CB1 antagonist, per kg body weight formulated in 100 µl sodium carboxymethylcellulose (NaCMC) for 20 consecutive days. The same volume of NaCMC was utilized as the vehicle control. (A–B), body weight profile of WT (A) and KO (B) mice during the 20 days of treatment. N = 5, *p<0.05 when compared with wild type controls.