Table 1.

Laboratory features of TMA

Full blood count: severe thrombocytopenia and anaemia

Blood film: red cell fragmentation (‘schistocytosis’ >1%), also polychromasia (reticulocytosis), absent or giant platelets

Coombs test: negative

Haemolysis screen: hyperbilirubinaemia (unconjugated), elevated LDH and reticulocyte count, low serum haptoglobins, free haemoglobin in serum and urine

Liver enzymes and coagulation screen: normal

Serum creatinine: elevated in renal involvement