Table 4.
Diagnostic tests
| Shiga toxin |
| Stool culture for E. coli plus either toxicology for shiga toxin or PCR for shiga toxin gene |
| Urine culture for E. coli |
| Other bacterial testing as indicated |
| S. pneumoniae |
| T antigen expression on red cells |
| PCR of blood and/or secretions |
| Blood culture |
| Complement dysregulation |
| Plasma/serum protein levels |
| C3 |
| Factor H, factor I, factor B |
| MCP (CD46) expression on PBMCs |
| Factor H autoantibodies |
| Mutations |
| Direct exon sequencing of CFH, MCP, CFI, CFB, C3 |
| Copy number variation across CFH-CFHR locus |
| ADAMTS13 deficiency |
| ADAMTS13 activity |
| ADAMTS13 autoantibodies |
| ADAMTS13 mutations |
| Other associations |
| Pregnancy test |
| Liver and pancreas enzymes |
| Cobalamin (B12), homocysteine assay, methylmalonic acid (plasma and urine) ± mutation analysis of MMACHC gene |
| HIV and other viral serology as indicated |
| ANA, lupus anticoagulant, antiphospholipid antibodies |
| Pharyngeal swab and viral PCR for influenza A (H1N1) |