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. Author manuscript; available in PMC: 2012 Jul 17.
Published in final edited form as: Cell Signal. 2011 Apr 21;23(9):1433–1440. doi: 10.1016/j.cellsig.2011.04.007

Figure 2. MOB signalling in mitosis and morphogenesis in Saccharomyces cerevisiae.

Figure 2

(A) Mob1p together with the Ste20-like kinase Cdc15p activates the Dbf2p NDR/LATS kinase. The Mob1p/Dbf2p complex phosphorylates the phosphatase Cdc14p, thereby triggering mitotic exit of yeast cells. (B) Mob2p cooperates with the Ste20-like kinase Kic1p to stimulate the Cbk1p NDR/LATS kinase. The Mob2p/Cbk1p complex targets Ace2p and other factors to regulate Ace2p activity and cellular morphogenesis (RAM). Of note, Mob1p functions in complex with Dbf2p and not Cbk1p, and Mob2p functions together with Cbk1p and not Dbf2p. Signalling components are not interchangeable. Ste20-like kinases are in yellow. NDR/LATS kinases are green, and MOB proteins are shown in red. Phosphorylations are indicated by “P” in blue.