Table 7.

Comparison of studies evaluating SERT binding in patients with depression

Study	Patients	N	Imaging Modality	Findings regarding SERT binding
Mallison et al. (1998)	MDD	15	[123I] β-CIT SPECT	Decreased brainstem
Willeit et al. (2000)	SAD	11	[123I] β-CIT SPECT	Decreased in thalamus but not midbrain
Eggers et al. (2003)	Wilson’s Dis	23	[123I] β-CIT SPECT	Decreased thalamus associated with depression
Reivich et al. (2004)	MDD	4	[11C](+)McN5652 PET	Increased in the frontal and cingulate cortices
Meyer et al. (2004)	MDD	20	[11C]DASB PET	No difference between MDD and controls, but increased in prefrontal cortex, anterior cingulate, and thalamus in patients with most depressive symptoms
Newberg et al. (2005)	MDD	7	[123I] ADAM SPECT	Decreased in midbrain
Parsey et al. (2006)	MDD	25	[11C](+)McN5652 PET	Decreased in midbrain and amygdala
Lehto et al. (2006)	Depression	29	[123]nor-β-CIT SPECT	Decreased in atypical and melancholic compared to controls, but not different in “undifferentiated” depression
Joensuu et al. (2007)	MDD	29	[123]nor-β-CIT SPECT	Decreased in midbrain
Joensuu et al. (2010)	MDD	23	[123]nor-β-CIT SPECT	Decreased medial prefrontal cortex in patients homozygous for the short allele of serotonin-transporter-linked polymorphic region gene
Hammoud et al. (2010)	HIV	18	[11C]DASB PET	HIV patients were decreased compared to controls, but depressed patients had relatively higher binding compared to non-depressed HIV patients
Hsieh et al. (2010)	MDD Hx	13	[123I] ADAM SPECT	No difference in euthymic patients with history of MDD
Chou et al. (2010)	Bipolar	28	[123I] ADAM SPECT	Decreased in midbrain in euthymic patients with Bipolar I Disorder but not Bipolar II Disorder
Ruhé et al. (2009)	MDD	49	[123I] β-CIT SPECT	Males had decreased midbrain compared to controls, but not women, and higher binding in all groups was found in the winter