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. Author manuscript; available in PMC: 2013 Jul 13.
Published in final edited form as: Mol Cell. 2012 May 31;47(1):50–60. doi: 10.1016/j.molcel.2012.04.028

Figure 5. Crystal structures for Atl1 in complex with ODN containing O6-HOEtG (cyan) O6-PrG (green), O6-BnG (magenta), or O6-CMG (yellow).

Figure 5

(A) Structural overlay of Atl1:ODN complexes showing similar DNA bend.

(B) Molecular surface of Atl1 lesion-binding pocket colored by hydrophobicity (white=most hydrophobic; red=least hydrophobic) and overlaid with Atl1:ODN complex structures. Trp 56 and Pro 50 are shown for reference.

(C–F) Binding of O6-HOEtG (C), O6-PrG (D), O6-BnG (E), and O6-CMG (F) within the Atl1 binding pocket. 2Fo-Fc omit electron density (blue) is shown for each O6-alkylG adduct (orange). Hydrogen bonds are shown as dashed green lines. The accompanying crystallographic data are listed in Table 1.