Simulated systems: trp-cage (A), melittin (B), and melittin surrounded by 8 protein G crowders in PRIMO representation (C). One of the crowders in C is omitted for clarity. Peptides are colored as follows: hydrophobic residues are shown in white, polar residues in green, basic residues in blue, and acidic residues in red, and the N-terminus is indicated with a purple bead. Crowder proteins are colored by chain.