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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Virus Res. 2012 May 23;167(2):273–284. doi: 10.1016/j.virusres.2012.05.010

Figure 8.

Figure 8

HSV-2 late phase inhibition of STAT2 phosphorylation abrogates translocation of STAT2 from the cytoplasm to the nucleus. (A) Mock-infected or HSV-2-infected 293α/β cells were mock-treated or treated with IFNβ, separated into cytoplasmic and nuclear fractions, and analyzed by western for STAT2 (αSTAT2) and phosphorylated STAT2 (αPO4 STAT2) proteins. Parallel experiments were conducted in the presence of the viral DNA replication inhibitors PAA or acyclovir. (B) Immunofluorescence analysis of STAT2 (green) and phosphorylated STAT2 (green) 293α/β cellular localization under the indicated conditions. Nuclei are demarcated in blue by Hoescht staining.