Table II.
Allele and genotype frequencies of p53 SNP72 and mdm2 SNP309 in CCA vs. controls.
| Frequency type | CCA n (%) | Controls n (%) | P-value | |
|---|---|---|---|---|
| Alleles | ||||
| p53 SNP72 | G | 265 (72.8) | 512 (73.1) | 0.92 |
| C | 99 (27.2) | 188 (26.9) | (0.98)a | |
| 364 (100) | 700 (100) | [0.74–1.31]b | ||
| mdm2 SNP309 | T | 228 (62.6) | 447 (63.9) | 0.70 |
| G | 36 (37.4) | 253 (36.1) | (0.95)a | |
| 364 (100) | 700 (100) | [0.73–1.23]b | ||
| Genotypes | ||||
| p53 SNP72 | GG | 94 (51.7) | 190 (54.3) | 0.49 |
| GC | 77 (42.3) | 132 (37.7) | (1.42)c | |
| CC | 1 (6.0) | 28 (8.0) | ||
| 182 (100) | 350 (100) | |||
| mdm2 SNP309 | TT | 74 (40.7) | 141 (40.3) | 0.62 |
| TG | 80 (44.0) | 165 (47.1) | (0.97)c | |
| GG | 28 (15.3) | 44 (12.6) | ||
| 182 (100) | 350 (100) | |||
a
Odds ratio;
b
95% confidence interval;
c
χ2 for 2×3 contingency tables.
SNP, single nucleotide polymorphism; mdm, murine double minute; CCA, cholangiocarcinoma.