Table III.
Genotypic interaction between p53 and mdm2 variants.
| Genotypes | CCA n (%) | Controls n (%) | P-value | |
|---|---|---|---|---|
| p53 SNP72 | ||||
| GG | SNP309 | 94 (100) | 190 (100) | 0.74 |
| TT | 34 (36.2) | 69 (36.3) | (0.6)a | |
| TG | 44 (46.8) | 95 (50.0) | ||
| GG | 16 (17.0) | 26 (13.7) | ||
| GC | SNP309 | 77 (100) | 132 (100) | 0.66 |
| TT | 31 (40.3) | 58 (43.9) | (0.83)a | |
| TG | 34 (44.1) | 59 (44.7) | ||
| GG | 12 (15.6) | 15 (11.4) | ||
| CC | SNP309 | 11 (100) | 28 (100) | 0.24b |
| TT | 9 (81.8) | 14 (50.0) | ||
| TG | 2 (18.2) | 11 (39.3) | ||
| GG | 0 (0) | 3 (10.7) | ||
| mdm2 SNP309 | ||||
| TT | SNP72 | 74 (100) | 141 (100) | 0.85 |
| GG | 34 (36.2) | 69 (49.0) | (0.32)a | |
| GC | 31 (46.8) | 58 (41.1) | ||
| CC | 9 (17.0) | 14 (9.9) | ||
| TG | SNP72 | 80 (100) | 165 (100) | 0.29 |
| GG | 44 (40.3) | 95 (57.5) | (2.47)a | |
| GC | 34 (44.1) | 59 (35.8) | ||
| CC | 2 (15.6) | 11 (6.7) | ||
| GG | SNP72 | 28 (100) | 44 (100) | 0.38b |
| GG | 16 (81.8) | 26 (59.1) | ||
| GC | 12 (18.2) | 15 (34.1) | ||
| CC | 0 (0) | 3 (6.8) | ||
a
χ2 for 2×3 contingency tables;
b
Fisher’s exact test;
SNP, single nucleotide polymorphism; mdm, murine double minute; CCA, cholangiocarcinoma.