Table IV.
Allelic interaction between p53 and mdm2 variants.
| Genotypes | CCA n (%) | Controls n (%) | P-value | |
|---|---|---|---|---|
| p53 SNP72 | ||||
| GG | SNP309 | |||
| T | 112 (59.6) | 223 (58.7) | 0.86 | |
| G | 76 (40.4) | 147 (38.7) | (1.03)a | |
| 188 (100) | 380 (100) | [0.72–1.47]b | ||
| GC | SNP309 | |||
| T | 96 (62.3) | 175 (66.3) | 0.41 | |
| G | 58 (37.7) | 89 (33.7) | (0.84)a | |
| 154 (100) | 264 (100) | [0.56–1.27]b | ||
| CC | SNP309 | |||
| T | 20 (90.9) | 39 (69.6) | 0.049 | |
| G | 2 (9.1) | 17 (30.4) | (4.36)a | |
| 22 (100) | 56 (100) | [0.92–20.77]b | ||
| mdm2 SNP309 | ||||
| TT | SNP72 | |||
| G | 99 (66.9) | 196 (69.5) | 0.58 | |
| C | 49 (33.1) | 86 (30.5) | (0.89)a | |
| 148 (100) | 282 (100) | [0.58–1.36]b | ||
| TG | SNP72 | |||
| G | 122 (76.3) | 249 (75.5) | 0.84 | |
| C | 38 (23.7) | 81 (24.5) | (0.96)a | |
| 160 (100) | 330 (100) | [0.62–1.49]b | ||
| GG | SNP72 | |||
| G | 44 (78.6) | 67 (76.1) | 0.74 | |
| C | 12 (21.4) | 21 (23.9) | (0.87)a | |
| 56 (100) | 88 (100) | [0.39–1.95]b | ||
a
Odds ratio;
b
95% confidence interval.
SNP, single nucleotide polymorphism; mdm, murine double minute; CCA, cholangiocarcinoma.