Table I.
IC50 values indicating the sensitivity of the gastric cancer cell line SGC7901 and its variants to VCR.
| Cell lines | IC50 value (μg/ml; mean ± SD) |
|---|---|
| SGC7901 | 0.85±0.11 |
| SGC7901-SATB1 | 1.53±0.45a |
| SGC7901-siRNASATB1 | 0.31±0.11 |
| SGC7901/VCR | 3.15±0.37a |
| SGC7901/VCR-SATB1 | 4.66±0.38 |
| SGC7901/VCR-siRNASATB1 | 1.61±0.15b |
IC50 values were calculated based on MTT assay and presented as the mean ± SD of three independent experiments.
a
P<0.01 vs. the control SGC7901 cells;
b
P<0.05 vs. the control SGC7901/VCR cells.
SATB1, special AT-rich sequence binding protein 1; VCR, vincristine.