Table II.

Intracellular VCR accumulation and retention in the gastric cancer cell line SGC7901 and its variants.

Cell lines	Accumulation	Retention
SGC7901	74.48±5.54	52.71±6.59
SGC7901-siRNASATB1	86.32±4.48a	33.75±3.41a
SGC7901-SATB1	64.25±3.60	33.75±3.41
SGC7901/VCR	28.14±1.58c	15.85±1.70c
SGC7901/VCR-siRNASATB1	33.56±5.87	18.97±1.20
SGC7901/VCR-SATB1	20.56±2.31b	8.54±1.05b

The values of VCR accumulation and retention were measured by flow cytometry and presented as the mean ± SD of three independent experiments.

^aP<0.05 and

^bP<0.05 vs. their respective control cells.

^cP<0.01, SGC7901 vs. SGC7901/VCR cells.

SATB1, special AT-rich sequence binding protein 1; VCR, vincristine.