Figure 2.

Right panel: Venn diagram of differentially expressed genes (numbers of upregulated genes are shown in green and downregulated in red). Left panel: The heatmap of the expression of genes that were differentially expressed by at least two virus subtypes. The PSG family, ANKRD1 and IFIT2 were upregulated by all three HPV subtypes. ABL2, MGLL and CYR61, which have angiogenic and oncogenic potential, were upregulated by HPV16 and -45. IFI44 and DDX60 were upregulated by HPV11 and downregulated by HPV16 and -45. There were 16 genes that were significantly downregulated by at least two HPVs. These gene showed tendency to be downregulated across all 3 type, among them we find ANKRD11, AOAH, FOXN1 and the oncogene BCL11A. Lists of all the differentially expressed genes are available in Supplement 2. The upregulated genes are depicted in red, downregulated in blue, and not differentially expressed in white.