Figure 3. Heatmap showing the expression of differentially expressed genes upon transfection with HPV11, -16 or -45 genomes.
The genes were grouped into six clusters. Clusters 2, 5 and 6 were enriched with cell cycle and DNA repair genes from BRCA1 (clusters 2 and 5) and BRCA2 (cluster 6) networks27. Cluster 4 was enriched with JUN transcription factor target genes and cluster 3 was enriched with interferon response genes. The genes of each of the six clusters are listed in Supplement 3. The upregulated genes are depicted in red, downregulated in blue, and not differentially expressed in white.