Table 1.
Reported involvement of MDSC in transplantation.
Phenotype | Species | Models | Mechanisms | Reference |
---|---|---|---|---|
CD3-ClassII-CD11b+CD80/86+ | Rat | Renal transplant tolerance | Accumulation; iNOS | Dugast et al. (2008) |
Gr-1+CD11b+ | Mouse | GVHD inhibition | Altered Ag processing by DC | Ghansah et al. (2004), Paraiso et al. (2007) |
CD115+Gr-1+F4/80+ | Mouse | GVHD prevention | IL-10; iNOS | Zhou et al. (2010) |
CD11b+Ly6GlowLy6C+ | Mouse | GVHD inhibition | Arg1 | Highfill et al. (2010) |
Gr-1+CD11b+ | Mouse | Skin allograft; long-term survival | iNOS | Adeegbe et al. (2010) |
Gr-1+CD11b+ | Mouse | Skin allograft; long-term survival | Arg1 | Zhang et al. (2008) |
Gr-1+CD11b+ IL-4Rα+ | Mouse | Islet allograft tolerance | C/EBPβ factor; Arg1; iNOS | Marigo et al. (2010) |
Gr-1+CD115+CD11b+ | Mouse | Cardiac transplant tolerance | IFN-γ-dependent pathways | Garcia et al. (2010) |
CD33+HLA-DR-CD11b+CD14+/- | Human | Renal transplantation | Accumulation | Hock et al. (2012) |