Table 2.

Logistic regression models for HbA1c and risk of future depressive symptoms over 2 yrs follow up in ELSA (n=4338). Cases defined as a score ≥4 on the 8 item CES-D scale

	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
	All (n=4338, cases=498)
A1C (per unit)	1.17 (1.03 – 1.33)	1.12 (0.98 – 1.28)	1.08 (0.91 – 1.29)
p-value	0.02	0.09	0.35
Men (n=1961, cases=154)
A1C (per unit)	1.23 (1.04 – 1.46)	1.19 (0.99 – 1.44)	1.20 (0.95 – 1.52)
p-value	0.02	0.07	0.13
Women (n=2377, cases=344)
A1C (per unit)	1.14 (0.94 – 1.38)	1.10 (0.90 – 1.33)	0.96 (0.75 – 1.25)
p-value	0.18	0.35	0.78

Model 1 adjusted for age and baseline CES-D score.

Model 2 plus smoking, alcohol intake, physical activity, social status

Model 3 plus C-reactive protein, cholesterol, body mass index, self reported diabetes.