Table 3.

a. Association between baseline diabetes status (using fasting glucose)^† and risk of future depressive symptoms (n= 2930)^*

	Cases/N	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
		Non-diabetic	220/2244	1.00	1.00	1.00
IFG	35/385	0.86 (0.57 – 1.30)	0.94 (0.62 – 1.43)	0.92 (0.60 – 1.39)
Diabetic	50/301	1.57 (1.07 – 2.29)	1.55 (1.05 – 2.30)	1.52 (1.01 – 2.30)
p-trend		0.038	0.071	0.08
b. Association between baseline diabetes status (using glycated haemoglobin)‡ and risk of future depressive symptoms (n= 4338)
Non-diabetic	397/3712	1.00	1.00	1.00
IGT	46/280	1.53 (1.05 – 2.24)	1.39 (0.94 – 2.04)	1.37 (0.93 – 2.02)
Diabetic	55/346	1.46 (1.02 – 2.07)	1.35 (0.94 – 1.92)	1.36 (0.94 – 1.97)
p-trend		0.016	0.087	0.105

Model 1 adjusted for age and baseline CES-D score.

Model 2 adjusted as model 1 plus for sex, smoking, alcohol intake, physical activity, social status

Model 3 adjusted as model 2 plus for C-reactive protein, cholesterol, body mass index.

^†Diabetes categories based on fasting glucose and self report; non-diabetic (fasting glucose <5.6 mmol/l and no self-reported diabetes), impaired fasting glucose [IFG] (fasting glucose= 5.6-6.9 mmol/l), diabetic (based on either fasting glucose ≥7.0 mmol/l, self reported doctors diagnosis or use of diabetes medication).

^*data unavailable in1408 participants.

^‡Diabetes categories based on A1C values and self report; non-diabetic (A1C <6 % and no self-reported diabetes), impaired glucose tolerance [IGT] (A1C= 6.0 – 6.5 % and no self-reported diabetes), diabetic (based on either A1C >6.5%, self reported doctors diagnosis or use of diabetes medication).