Skip to main content
. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: Neuron. 2012 Jul 12;75(1):108–120. doi: 10.1016/j.neuron.2012.05.025

Figure 5.

Figure 5

Dendritic plasticity enhances parallel fiber burst signaling. (A) Recording configuration. PF responses were measured before and after application of the somatic depolarization protocol. (B) Repeated somatic depolarization does not alter the first EPSP in a 10Hz EPSP train, but enhances amplification of subsequent EPSPs. Left traces: dendritic (red) and somatic (black) baseline responses. Right traces: 20min after tetanization. (C) Tetanization enhances the facilitation within 50Hz EPSP trains. (D) EPSP facilitation within 10Hz trains before (open dots) and after tetanization (closed dots) in the dendrite (left) and soma (right; n=9). In the presence of spikes, the EPSP amplitude was measured as the amplitude of the slow response component. EPSP amplitudes were normalized to the amplitude of EPSP 1 in the same train. (E) The probability of spike firing was enhanced for the late EPSPs within a 50Hz EPSP train (n=8). The PF-EPSP train measures were obtained during the experiments shown in Figs. 2B and 3. Three to nine sweeps were collected at minutes −10 to −7 (baseline), three sweeps were collected at minute −1 (before tetanization), and nine sweeps or more were collected at minutes +20 to 30 (after tetanization). Error bars indicate SEM.