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Double immunofluorescent staining for microglia (Iba1) and Aβ protein (10D5) in the cerebral cortex of a human with Down syndrome reveals apparently normal, non-activated microglia in and around Aβ deposits. Microglia are ramified and show no evidence of having internalized any Aβ protein. Two microglial cells show presence of intracellular, autofluorescent lipofuscin (arrows). Scale bar: 50 μm.
