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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Otolaryngol Clin North Am. 2012 Aug;45(4):807–822. doi: 10.1016/j.otc.2012.04.005

Figure 1. HPV-16 Genome.

Figure 1

The circular HPV-16 genome is 7904 base pairs and encodes six early (E) and two late (L) major proteins. The primary cellular targets of these proteins are indicated on the genome diagram: E6 ubiquitinates p53, E7 competes for binding with E2F to the hypophosphorylated “active” form of retinoblastoma tumor suppressor gene product (pRB), and E5 up-regulates epidermal growth factor receptor (EGFR).