. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Otolaryngol Clin North Am. 2012 Aug;45(4):807–822. doi: 10.1016/j.otc.2012.04.005

Table I.

Differences between Prophylactic and Therapeutic Vaccines

	Prophylactic Vaccine	Therapeutic Vaccine
Prevent new infection	Yes	No
Treat existing infection	No	Yes
Effector Cells	B cells	CD4+ T cells, CD8+ T cells
Humoral (Antibody) Response	High	Low
Cell Mediated (T-cell) Response	Low	High
Vaccine construction	Whole organism – live / attenuated / killed; Protein subunits	DNA plasmid; Peptides/proteins; Dendritic cell
Targeted antigen	Cell surface viral capsid protein	Intracellular viral protein