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. Author manuscript; available in PMC: 2012 Jul 17.
Published in final edited form as: N Engl J Med. 2008 Jan 10;358(2):140–151. doi: 10.1056/NEJMoa063564

Figure 1. Overview of Screening, Enrollment, and Follow-up of the Patients with the Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM).

Figure 1

Angiomyolipoma volumes and pulmonary-function tests in patients with LAM were assessed during the period of sirolimus treatment, from baseline to 12 months, and during a post-treatment observation period, from 12 to 24 months. At baseline, 18 patients had LAM, but pulmonary data were uninterpretable in 2 patients because of chylothorax or pneumothorax. At the 12-month time point, one patient declined to undergo pulmonary-function tests, and four patients had withdrawn from the study. One patient withdrew during the second year.