. Author manuscript; available in PMC: 2013 Apr 1.

Published in final edited form as: Cancer Discov. 2012 Jan 27;2(4):356–365. doi: 10.1158/2159-8290.CD-11-0241

Table 2.

Correlation matrix of mediators that regulate aromatase expression.

	COX-2 mRNA	COX-2 protein	PGE₂ level	cAMP level	PKA activity	Aromatase expression	Aromatase PI.3	Aromatase PII	Aromatase Activity	PR protein
BMI	0.43^†	0.36^‡	0.50^*	0.41^†	0.37^†	0.42^†	0.28^‡	0.35^‡	0.50^*	0.54^*
CLS-B index	0.60	0.83	0.85	0.83	0.79	0.75	0.66	0.71	0.88	0.91

COX-2 protein	0.69	-	-	-	-	-	-	-	-	-
PGE₂ level	0.62	0.83	-	-	-	-	-	-	-	-
cAMP level	0.64	0.89	0.96	-	-	-	-	-	-	-
PKA activity	0.63	0.82	0.94	0.90	-	-	-	-	-	-
Aromatase expression	0.60	0.62	0.74	0.62	0.65	-	-	-	-	-
Aromatase P1.3	0.42^†	0.57^*	0.54^*	0.51^*	0.51^*	0.58^*	-	-	-	-
Aromatase PII	0.45^†	0.62	0.59	0.60	0.61	0.73	0.87	-	-	-
Aromatase Activity	0.57^*	0.75	0.82	0.85	0.76	0.60	0.63	0.64	-	-
PR protein	0.41^†	0.71	0.78	0.73	0.73	0.60	0.52^*	0.55^*	0.73	1.0

Each number represents the Spearman’s rank correlation coefficient of the levels of the two corresponding mediators in the study population. Most of the correlation coefficients are statistically significantly different from 0 (P<0.001, *P<0.01, †P<0.05, ‡P≥0.05).