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. 2012 Jul 4;18:1828–1839.

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Copyright © 2012 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Corneal scarring and keratocyte cell density in rabbit corneas 3 months after lamellar keratectomy in eyes treated with and without MMC. Second harmonic (A and B) and confocal imaging of the same plane stained with Syto59 (C and D) of control (A and C) and 0.2 mg/ml MMC treated corneas (B and D) 2 months before lamellar keratectomy injury. Control corneas 3 months after LK injury showed the presence of irregularly organized scar collagen (A) and a high density of scar fibroblast nuclei (B). By comparison, eyes treated with MMC 2 months before LK injury showed normal lamellar stromal collagen at the epithelial-stromal interface (C) and markedly decreased corneal keratocytes (D) 3 months after LK injury.