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. 2012 Jul 4;18:1813–1822.

Table 3. SSH differentially expressed genes validated by cDNA microarray analysis (fold-change >-1.5).

Genes Chromosomal location GenBank accession# Biological process SSH redundancy Microarray fold-change UMI/UVM Microarray fold-change UMII/UVM
ADAM metallopeptidase domain 10 (ADAM10) 15q22 NM_001110 NOTCH signaling 1 −6.37 −2.68
Adenosylhomocysteinase-like 1 (AHCYL1) 1p13.2 NM_006621 Ion transport 1 −1.51 −1.10
Alpha-kinase 1 (ALPK1) 4q25 NM_025144 Protein phosphorylation 1 −4.19 −2.46
ATPase H+ transporting lysosomal 70 kDa V1 subunit A (ATP6V1A) 3q13.31 NM_001690 ATP hydrolysis 1 −5.37 −6.27
BCL2-associated transcription factor 1 (BCLAF1) 6q23 NM_014739 Apoptosis 1 −4.83 −1.33
Calumenin (CALU) 7q32.1 NM_001219 Calcium binding 5 −2.01 −1.51
Casein kinase 1 gamma 1 (CSNK1G1) 15q22.31 NM_022048 WNT signaling 1 −1.50 −1.51
Casein kinase 2 alpha prime polypeptide (CSNK2A2) 16q21 NM_001896 WNT signaling 1 −1.12 −1.75
Catenin (cadherin-associated protein) beta 1 (CTNNB1) 3p21 NM_001904 WNT signaling 4 −1.38 −2.33
Cathepsin A (CTSA) 20q13.1 NM_000308 Protein transport 1 −4.07 −6.00
CCR4-NOT transcription complex subunit 2 (CNOT2) 12q15 NM_014515 RNA splicing 2 −2.12 −1.67
Chromosome 7 open reading frame 64 (C7orf64) 7q21.2 NM_032120 Nucleotide metabolism 1 −2.10 −2.25
Coatomer protein complex subunit beta 2 (COPB2) 3q23 NM_004766 Protein transport 1 −1.30 −1.66
Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 (DPAGT1) 11q23.3 NM_001382 Protein glycosylation 1 −1.56 −1.41
Dopachrome tautomerase (DCT) 13q32 NM_001922 Melanocyte differentiation 4 −22.30 −89.81
Drosha RNase type III (DROSHA) 5p13.3 NM_013235 Gene silencing 1 −2.08 1.10
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) 1p36.12 NM_003760 Translation 1 −5.41 −1.43
Glucosidase beta acid (GBA) 1q21 NM_000157 Glycolipid metabolism 1 −3.67 −3.40
H2A histone family member Z (H2AFZ) 4q24 NM_002106 Embryonic development 2 −1.72 −3.18
Integrin beta 8 (ITGB8) 7p21.1 NM_002214 Cell adhesion 1 −1.90 −1.33
Isoleucine-tRNA synthetase (IARS) 9q21 NM_013417 Translation 1 −1.66 1.17
Karyopherin alpha 2 (KPNA2) 17q24.2 NM_002266 Cell cycle 1 −1.15 −1.50
Lactate dehydrogenase B (LDHB) 12p12.1 NM_002300 Glycolysis 1 −1.68 1.97
Leucyl-tRNA synthetase (LARS) 5q32 NM_020117 ATP hydrolysis 1 −2.57 −1.08
Lysosomal trafficking regulator (LYST) 1q42.3 NM_000081 Pigmentation 1 −5.59 −5.15
Malectin (MLEC) 12q24.31 NM_014730 Protein glycosylation 1 −1.61 −1.36
RAB27A member RAS oncogene family (RAB27A) 15q21.3 NM_004580 Melanocyte differentiation 3 −2.64 −1.76
Microophthalmia-associated transcription factor (MITF) 3p14.1 NM_198159 Melanocyte differentiation 1 −2.91 −2.11
NHS-like 1 (NHSL1) 6q23.3 NM_020464 Unknown 1 −1.95 −2.35
Nucleoporin 93 kDa (NUP93) 16q13 NM_014669 Glycolysis 1 −2.18 −2.16
Plasma glutamate carboxy-peptidase (PGCP) 8q22.2 NM_016134 Proteolysis 2 −4.78 −4.30
Prosaposin (PSAP) 10q21 NM_002778 Lipid metabolism 1 −1.39 −1.87
Prostaglandin reductase 1 (PTGR1) 9q31.3 NM_012212 LTB4 metabolism 1 −2.22 −1.17
Protein kinase D3 (PRKD3) 2p21 NM_005813 PKC signaling 1 −3.59 −2.69
Radixin (RDX) 11q23 NM_002906 Microvillus assembly 1 −1.71 −1.07
Ras-like without CAAX 1 (RIT1) 1q22 NM_006912 NGFR signaling 1 −1.27 −1.67
Recombination signal binding protein for immunoglobulin kappa J region (RBPJ) 4p15.2 NM_005349 NOTCH signaling 2 −6.66 −3.94
Retinol dehydrogenase 11 (RDH11) 14q24.1 NM_016026 Retinoid metabolism 1 −10.21 −8.28
Serine carboxy-peptidase 1 (SCPEP1) 17q22 NM_021626 Retinoic acid metabolism 1 −2.52 −3.29
Signal peptidase complex subunit 1 (SPCS1) 3p21.1 NM_014041 Insulin secretion 1 1.68 −1.50
Solute carrier family 11 member 2 (SLC11A2) 12q13 NM_000617 Iron absorption 1 −7.21 −5.27
Solute carrier family 16 member 6 (SLC16A6) 17q24.2 NM_004694 Glycolysis 2 −181.62 −46.58
Solute carrier family 25 member 5 (SLC25A5) Xq24 NM_001152 Cell respiration 1 −1.37 −1.61
Sorting nexin family member 27 (SNX27) 1q21.3 NM_030918 Protein transport 5 −1.61 −1.09
Sperm associated antigen 5 (SPAG5) 17q11.2 NM_006461 Cell cycle 1 −1.80 −1.14
Subunit of the oligosaccharyl-transferase complex homolog A (STT3A) 11q23.3 NM_152713 Protein glycosylation 2 −2.03 −1.68
Transaldolase 1 (TALDO1) 11p15.5 NM_006755 Cell respiration 1 −1.23 −1.87
Transcription elongation factor B (SIII) polypeptide 1 (TCEB1) 8q21.11 NM_005648 Transcription 1 −1.65 2.43
Transferrin receptor (TFRC) 3q29 NM_003234 Response to hypoxia 1 −4.40 −4.12
Transient receptor potential cation channel subfamily M member 1 (TRPM1) 15q13.3 NM_002420 Melanocyte differentiation 1 −19.16 −14.62
Translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1) 3q13.33 NM_016589 Protein transport 1 −1.51 −2.32
Tyrosinase (TYR) 11q14.3 NM_000372 Melanocyte differentiation 1 −11.23 −15.84
Tyrosinase-related protein 1 (TYRP1) 9p23 NM_000550 Melanocyte differentiation 10 −7.67 −11.58
Ubiquitin specific peptidase 4 (USP4) 3p21.3 NM_003363 Protein deubiquitination 1 −2.61 −3.02
Vacuolar protein sorting 35 (VPS35) 16q12 NM_018206 Protein transport 4 −1.18 −1.72