Table 2.

Individual activity of respiratory chain enzyme complexes and ratio over CS

Parameter	HFD-fed WT mice		HFD-fed Sirt3−/− mice
	Activity	Activity/CS ratio	Activity	Activity/CS ratio
Complex I	15.7 (2.7–21.2)	83 (16–124)	10.7 (2.4–12.9)	58 (14–65)
Complex II	85.8 (49.3–118.5)	436 (290–703)	65.5 (54.8–123.4)	387 (326–554)
Complex III	3.0 (1.7–5.3)†	14 (10–35)†	0.7 (0.6–1.2)	4 (3–7)
Complex II+III	5.1 (4.1–7.8)	33 (23–46)	4.0 (3.3–6.5)	23 (15–39)
Complex IV	5.3 (4.3–10.3)†	31 (23–67)†	2.7 (2.4–3.3)	15 (14–19)
CS	170.1 (154.6–221.9)	NA	171.6 (166.3–222.9)	NA

Values are medians (range).

^†P < 0.01 compared with Sirt3^−/−.

NA, not applicable.