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Proposed MKS1 Decarboxylase Reaction Mechanism.
The 3-keto acid substrate is positioned between Thr-18 and His-243 within the MKS1 active site. His-243 acts as a proton donor, thus facilitating decarboxylation through a concerted mechanism. Block arrow represents the shift in product orientation within the active site in relation to the substrate.
[See online article for color version of this figure.]
