Figure 4.



Tyrosine phosphorylation of enzymes involved in glycolysis and glycogen metabolism. Isoforms and/or subunits of enzymes involved in (A) glycolysis, (B) glycogen metabolism, and (C) regulation of muscle glycogen synthase (GYS1). Tyrosine phosphorylated proteins are shown in yellow boxes, and the number of identified tyrosine phosphorylation sites (pY) are indicated by red circles. Number of serine (Ser) residues on GYS1 indicates known Ser phosphorylation sites with their classical number of site given below the bar. AMPK, AMP-activated kinase; CaM-KII, calcium-calmodulin-dependent kinase II; CK1, casein kinase 1; CK2, casein kinase 2; DYRK1A, dual specificity tyrosine-phosphorylation-regulated kinase 1A; GSK3A, glycogen synthase kinase a; PHK, phosphorylase kinase; PKA, protein kinase A; PKC, protein kinase C.