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. 2012 Jul 4;2012:546039. doi: 10.1155/2012/546039

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Copyright © 2012 Jorge E. Toblli et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic representation of glomerular filtration barrier components. (a) Illustration of all participant structures in the normal glomerular filtration process. The rectangle indicates the tight relationship between the glomerular capillary wall, glomerular basement membrane, and glomerular visceral epithelial cell (podocyte) which is detailed in the lower panel. (b) Molecular structures of the podocyte and slit diaphragm. Abbreviations: ACTN4: α-actinin-4; CD2AP: CD2-associated protein; GEC: glomerular endothelial cell; ILK: integrin-linked kinase; ZO-1: tight junction protein ZO-1; CD151: tetraspanin CD151; TRPC6: transient receptor potential cation channel 6; NCK: protein adaptor NCK.