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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2012 May 18;1823(8):1273–1284. doi: 10.1016/j.bbamcr.2012.05.012

Figure 8. Model of HERG translation and key mediators.

Figure 8

A schematic representation of HERG synthesis at the ER and key mediators that regulate the process. The fully synthesized HERG monomer is shown at right on the ER membrane with cytosolic N and C-termini and six transmembrane domains. At left is shown a simplified view of the ribosomal complex as it translates HERG mRNA into protein. The large and small subunits join with the translocon complex to synthesize the nascent HERG peptide. PKA and increased levels of cAMP may be responsible for mediating synthesis or turnover of an unknown co-factor. Several possibilities exist for the role of the co-factor and may play a part in aiding or accelerating HERG synthesis.