Table.
Case Data
| Case | Braak and Braak Stage | CERAD plaque density/presence of senile plaques in hippocampus* | Cognitive status | Age (y) | Sex | PMI (h) | RIN |
|---|---|---|---|---|---|---|---|
| BM1 | 0 | None/0 | No neurological history and no evidence of dementia | 70 | M | 24 | 6.2 |
| BM2 | 0 | None/0 | No neurological history and no evidence of dementia | 73 | F | 25 | 4.5 |
| BM3 | 0 | None/0 | No neurological history and no evidence of dementia | 75 | F | 36 | 5.4 |
| BM4 | 0 | None/0 | No neurological history and no evidence of dementia | 77 | F | 46 | 4.5 |
| BVAX1 | I | Sparse/1+ (D) | CDR 0 | 77 | F | 6 | 4.8 |
| BVAX2 | I | None/0 | CDR 0 | 91 | F | 16 | 6.1 |
| BVAX3 | I | Sparse/1+ (N) | CDR 0 | 94 | M | 1.5 | 6.7 |
| BVAX4 | II | Sparse/1+ (D) | CDR 0 | 90 | M | 15 | 5.7 |
| BVAX5 | II | None/0 | CDR 0.5 | 96 | F | NA | 5.8 |
| BVAX6 | IV | Frequent, temporal only/ 2+ (N) | CDR 1 | 92 | M | NA | 5.7 |
| BVAX7 | IV | Moderate/ 2+ (N) | CDR 1 | 96 | F | 3.5 | 7.4 |
| MADRC1 | IV | Sparse/ 1+ (D & N) | Mild dementia | 103 | F | 5 | 6.0 |
*
0 = none; 1+ = mild; 2+ = moderate, 3+ = severe, 4+ = very severe.
BM1 – 4= Boston Medical Center cases 1–4; BVAX1-6 = Brain Bank of the Boston University Alzheimer Disease Center cases 1–6; CERAD = The Consortium to Establish a Registry for Alzheimer's Disease; CDR 0–1 = clinical dementia rating scores 0 – 1; D = diffuse plaques; F = female; M = male; MADRC1= Massachusetts Alzheimer Disease Research Center case 1; N = neuritic plaques; PMI = postmortem interval; RIN= RNA integrity number.