Table 2. Brain Areas Presenting Significant Functional Connectivity with dACC During Social Exclusion (ESE–ISE contrast), as Shown by PPI Analysis for (a) CS and ADS; (b) Group Comparison.

(a)
Group	Brain area	x	y	z	BA	L/R	P/N	k	t-Statistic	p-Value
CS	IFG	44	2	32	9	R	N	101	3.27	0.002
	VPFC	48	34	−4	47	R	N	97	2.61	0.008
	STG	−56	−4	−4	22	L	P	64	4.62	<0.001
	MFG	−30	6	48	6	L	N	60	4.51	<0.001
	STG	46	−26	8	41	R	P	53	3.1	0.003
	SFG	24	49	4	10	R	N	29	3.31	0.002
ADS	PHG	−24	−52	−10	19	L	P	249	2.83	0.005
	PrG	−40	−16	64	6	L	N	110	3.49	<0.001
	STG	44	−36	16	41	R	P	52	2.62	0.008

(b)
Comparison	Brain area	x	y	z	BA	L/R	P/N	k	t-Statistic	p-Value
CS>ADS	VPFC	−55	20	−2	47	L	N	275	3.93	<0.001
	MFG	4	−8	64	6	R	N	201	4.19	<0.001
	SFG	−26	40	42	8	L	N	199	3.19	0.002
	IFG	−58	10	20	45	L	N	134	3.27	0.001
	SFG	20	20	54	8	R	N	122	3.81	<0.001
	Thalamus	−18	−16	4	/	L	P	93	3.87	<0.001
	PrG	−38	−22	62	4	L	P	74	3.5	<0.001
	STG	50	−30	10	41	R	P	73	3.17	0.002
	MFG	−34	6	56	6	L	N	62	3.55	<0.001
	VPFC	49	18	2	47	R	N	41	3.01	0.001
	IFG	42	46	2	10	R	N	39	3.41	0.009
	PoG	−38	−34	62	3	L	P	32	3.2	0.001
ADS>CS	No significant activation

Abbreviation: ADS, alcohol-dependent subjects; BA, Brodmann area; CS, control subjects; dACC, dorsal anterior cingulate cortex; IFG, inferior frontal fyrus; k, cluster size; L, left hemisphere; MFG, middle frontal gyrus; N, negative connectivity; P, positive connectivity; PHG, parahippocampal gyrus; PoG, postcentral gyrus; PrG, precentral gyrus; R, right hemisphere; SFG, superior frontal gyrus; STG, superior temporal gyrus; VPFC, ventrolateral prefrontal cortex.

Threshold set at p<0.001 uncorrected with a minimum cluster size of 20 voxels.

x, y, and z are stereotaxic coordinates of peak-height voxels.