Figure 2.

Fear memory disruption induced by cannabidiol (CBD) or midazolam (MDZ) is restricted to the time window in which reconsolidation takes place. On the day following the contextual conditioning session described in Figure 1, the animals were reexposed to Context A for 3 min to reactivate the fear memory. Six hours later, they received intraperitoneal injections of vehicle (VEH), CBD (10 mg/kg), or MDZ (1.5 mg/kg). Neither CBD- nor MDZ-treated animals froze less than controls during Test A performed 24 h later. The arrowhead indicates the moment of drug treatment. Bars represent the percentage of freezing time. No statistically significant differences between groups were detected in this experiment.