Figure 5.

(a) Disruption of fear memory induced by cannabidiol (CBD) treatment is long lasting and context-specific. On the day following the contextual conditioning session in Context A (described in Figure 1), the animals were reexposed to Context A for 3 min to reactivate the established fear memory and then treated with vehicle (VEH) or CBD (10 mg/kg). CBD-treated animals froze less than controls when reexposed to the conditioned context (Test A) 1 week later. However, when memory reactivation was omitted (b), this result was no longer observed. The arrowhead indicates the moment of drug treatment. Bars represent the percentage of freezing time. The asterisk indicates significant difference (P<0.05) from respective controls.