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. 2012 May 2;37(9):2132–2142. doi: 10.1038/npp.2012.63

Figure 6.

Figure 6

A 7-day-old fear memory is also susceptible to disruption by cannabidiol (CBD). One week after the contextual conditioning session in Context A (described in Figure 1), the animals were reexposed to this chamber for 3 min to reactivate the fear memory, and immediately after received vehicle (VEH) or CBD (10 mg/kg). CBD impaired reconsolidation of the fear memory, which was evident during the reexposure to Context A (Test A) 24 h later. A similar effect of CBD effect was also present in a second Test A conducted 1 week later. No difference was found when animals were exposed to Context B (unpaired context). The arrowhead indicates the moment of drug treatment. Bars represent the percentage of freezing time. The asterisk indicates significant difference (P<0.05) from respective controls, and NS denotes a not statistically significant difference.