Table 2. Psychopathological Measures at Multiple Time Points During DBS Treatment.
| Baseline | 1 Month | 3 Months | 6 Months | 9 Months | 12 Months | 15 Months | 18 Months | 21 Months | 24 Months | Last observation | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| p-Value main effect | p-Value | p-Value | p-Value | p-Value | p-Value | p-Value | p-Value | p-Value | p-Value | p-Value | |
| HDRS_28 | |||||||||||
| Group | 32.2 (5.5) | 23.2 (5.6) | 23.4 (5.1) | 20.9 (4.6) | 23.3 (5.5) | 20.2 (7.5) | 21.3 (7.1) | 21 (8.9) | 21.5 (8.1) | 19.5 (9) | 22.1(13.4) |
| F=4.1 | p<0.001 | p<0.005 | p<0.001 | p=0.001 | p<0.005 | p<0.005 | p<0.005 | p<0.005 | p<0.01 | p<0.01 | p<0.05 |
| df=10 | |||||||||||
| MADRS | |||||||||||
| Group | 32.3 (3.7) | 24.2 (4.8) | 23.4 (4.7) | 20.9 (5.6) | 22.8 (6.8) | 20.2 (7.3) | 21.2 (7.8) | 21.1 (8.5) | 21.7 (9.3) | 19.1 (8.5) | 21.6 (10.7) |
| F=5.1 | p<0.001 | p<0.001 | p<0.001 | p<0.001 | p<0.005 | p=0.001 | p<0.005 | p<0.005 | p<0.05 | p<0.005 | p<0.05 |
| df=10 | |||||||||||
| HAMA | |||||||||||
| Group | 23.3 (5.7) | 17.9 (7.3) | 17.6 (5.9) | 15.4 (3.9) | 17.4 (3) | 14.3 (5.8) | 15.7 (9) | 16 (10.4) | 13.7 (6.4) | 13.9 (4.9) | 14.7 (8.8) |
| F=2.7 | p<0.005 | p<0.01 | p<0.05 | p<0.005 | p<0.005 | p<0.005 | p<0.05 | p<0.05 | p<0.005 | p=0.001 | p<0.05 |
| df=10 | |||||||||||
| Activities | |||||||||||
| Group | 28.5 (16) | 43.9 (24.8) | 39 (21.8) | 41.6 (24.4) | 43.2 (20.5) | 45.7 (20.7) | 45.5 (25.4) | 46.4 (25.3) | 48 (29.6) | 51.9 (35.5) | 57.9 (37.7) |
| F=2.4 | p<0.05 | p<0.05 | p<0.05 | p=0.100 | p<0.05 | p<0.05 | p=0.052 | p<0.05 | p=0.075 | p=0.083 | p<0.05 |
| df=10 | |||||||||||
| SF 36 | |||||||||||
| Mental health | |||||||||||
| Group | 19.4 (4.9) | 23.3 (6.3) | 19.5 (3.4) | 20.5 (6.5) | 19.9 (3.8) | 24.3 (11.4) | 29.9 (11.2) | ||||
| F=4.9 | p<0.001 | p<0.05 | p=0.953 | p=0.551 | p=0.749 | p=0.172 | p<0.05 | ||||
| df=6 | |||||||||||
| Physical health | |||||||||||
| Group | 34.0 (4.5) | 35.4 (7.9) | 38.0 (5.9) | 35.7 (4.6) | 34.8 (3.9) | 37.6 (8.5) | 34.1 (13.3) | ||||
| F=0.7 | p=0.651 | p=0.42 | p=0.40 | p=0.267 | p=0.565 | p=0.182 | p=0.980 | ||||
| df=6 | |||||||||||
Abbreviations: Activities, number of positive activities after Hautzinger; HAMA, Hamilton Anxiety Scale; HDRS_28, Hamilton-28-Items Depression Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; SF-36, Health Survey Questionnaire.
Mean, SD, ANOVAs for repeated measures with the factor time and post-hoc contrasts for each time point in comparison with baseline.