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. 2012 Jun 16;8(11):519–522. doi: 10.6026/97320630008519

Figure 1.

Figure 1

Design of siRNAs against DENV NSB4 and NS5 coding regions. A) Multiple alignment of the four DENV serotypes showing a fragment of the highly conserved NS4B encoding region (nt position 6910-7360) depicted in black. B) Alignment of the proposed siRNAs with the DENV consensus sequence (obtained by alignment of 215 DENV sequences). C) Three regions of DENV-2 genome structure showing the interaction sites with the proposed siRNAs (red circles). The arrows indicate the initial site of interaction.