Table 1.

Protective effect of metformin in animal models for cancer.

Cancer Model	Tumor type	Treatment	Route	Ref.
Xenograft	Pancreas	250 mg/kg	IP	[127]
	Lung	50 mg/kg	Oral	[158]
	Colon	250 mg/kg	IP	[142]
	Prostate	200 μg/ml 1 mg/day	Oral IP	[134]
	Breast	2 mg/ml	Oral	[138]
	Leukemia	250 mg/kg	IP	[124]
	Cancer stem cells	100 μg/ml	IP	[159]
chemically-induced	Breast	50–500 mg/kg	Oral	[160]
	Lung	250 mg/kg	IP	[161]
	Colon	250 mg/kg	IP	[162]
	Pancreas	320 mg/kg	Oral	[115]
HER2/neu mice	Breast	100 mg/kg	Oral	[118]
PTEN+/− mice	All	300 mg/kg	Oral	[119]
APCMin/+ mice	Gastrointestinal polyps	250 mg/kg	Oral	[120]