Table 1. Populations of moderate and great concern for Ag85B-ESAT-6.
Gene | Population of concern | Allele of concern 1 | f* | Allele of concern 2 | f* | Allele of concern 3 | f* | Phenotype Frequency |
HLA–A | China Guangxi Region Maonan | A*1101 | 0.352 | A*0207 | 0.134 | 0.236 | ||
China Guizhou Province Bouyei | A*1101 | 0.314 | A*0207 | 0.227 | 0.293 | |||
China Guizhou Province Miao pop 2 | A*1101 | 0.359 | A*0207 | 0.165 | 0.275 | |||
China Guizhou Province Shui | A*1101 | 0.295 | A*0207 | 0.175 | 0.221 | |||
China South Han | A*1101 | 0.277 | A*3303 | 0.115 | 0.154 | |||
China Southwest Dai** | A*1101 | 0.391 | A*0207 | 0.185 | 0.332 | |||
China Yunnan Province Bulang | A*1101 | 0.543 | 0.295 | |||||
China Yunnan Province Han | A*1101 | 0.317 | A*0207 | 0.183 | 0.250 | |||
China Yunnan Province Hani pop 2** | A*1101 | 0.613 | A*0207 | 0.107 | 0.518 | |||
China Yunnan Province Jinuo** | A*1101 | 0.367 | A*0207 | 0.188 | 0.308 | |||
China Yunnan Province Wa** | A*1101 | 0.584 | A*3303 | 0.160 | 0.554 | |||
India Kerala Hindu Pulaya** | A*1101 | 0.531 | A*0301 | 0.063 | 0.353 | |||
India New Delhi | A*1101 | 0.235 | A*0301 | 0.098 | 0.111 | |||
India Tamil Nadu Nadar | A*0301 | 0.205 | A*3101 | 0.189 | 0.155 | |||
Indonesia Java Western | A*1101 | 0.164 | A*3303 | 0.162 | 0.106 | |||
Indonesia Sudanese and Javanese | A*3303 | 0.169 | A*1101 | 0.164 | 0.111 | |||
Pakistan Baloch | A*1101 | 0.222 | A*3303 | 0.127 | 0.122 | |||
Pakistan Burusho | A*3303 | 0.179 | A*0301 | 0.130 | A*1101 | 0.125 | 0.188 | |
Thailand | A*1101 | 0.299 | A*0207 | 0.109 | 0.167 | |||
Thailand Northeast | A*1101 | 0.271 | A*0207 | 0.157 | 0.183 | |||
Thailand Northeast pop 2 | A*1101 | 0.233 | A*0207 | 0.144 | 0.142 | |||
Vietnam Hanoi Kinh pop 2 | A*1101 | 0.229 | A*3303 | 0.115 | 0.118 | |||
HLA–B | None | None | – | |||||
HLA–C | None | None | – | |||||
HLA-DRB1 | None | None | – |
Allele frequency, from the Allele*frequencies database.
Populations of great concern, defined as populations where 30% or more of the population has an expected phenotype of reduced protection by the vaccine due to having two alleles of concern for a single HLA locus, assuming Hardy-Weinberg equilibrium. Alleles of concern are defined as alleles predicted to bind four or fewer vaccine epitopes.