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. 2012 Jul 17;7(7):e40882. doi: 10.1371/journal.pone.0040882

Table 1. Populations of moderate and great concern for Ag85B-ESAT-6.

Gene Population of concern Allele of concern 1 f* Allele of concern 2 f* Allele of concern 3 f* Phenotype Frequency
HLA–A China Guangxi Region Maonan A*1101 0.352 A*0207 0.134 0.236
China Guizhou Province Bouyei A*1101 0.314 A*0207 0.227 0.293
China Guizhou Province Miao pop 2 A*1101 0.359 A*0207 0.165 0.275
China Guizhou Province Shui A*1101 0.295 A*0207 0.175 0.221
China South Han A*1101 0.277 A*3303 0.115 0.154
China Southwest Dai** A*1101 0.391 A*0207 0.185 0.332
China Yunnan Province Bulang A*1101 0.543 0.295
China Yunnan Province Han A*1101 0.317 A*0207 0.183 0.250
China Yunnan Province Hani pop 2** A*1101 0.613 A*0207 0.107 0.518
China Yunnan Province Jinuo** A*1101 0.367 A*0207 0.188 0.308
China Yunnan Province Wa** A*1101 0.584 A*3303 0.160 0.554
India Kerala Hindu Pulaya** A*1101 0.531 A*0301 0.063 0.353
India New Delhi A*1101 0.235 A*0301 0.098 0.111
India Tamil Nadu Nadar A*0301 0.205 A*3101 0.189 0.155
Indonesia Java Western A*1101 0.164 A*3303 0.162 0.106
Indonesia Sudanese and Javanese A*3303 0.169 A*1101 0.164 0.111
Pakistan Baloch A*1101 0.222 A*3303 0.127 0.122
Pakistan Burusho A*3303 0.179 A*0301 0.130 A*1101 0.125 0.188
Thailand A*1101 0.299 A*0207 0.109 0.167
Thailand Northeast A*1101 0.271 A*0207 0.157 0.183
Thailand Northeast pop 2 A*1101 0.233 A*0207 0.144 0.142
Vietnam Hanoi Kinh pop 2 A*1101 0.229 A*3303 0.115 0.118
HLA–B None None
HLA–C None None
HLA-DRB1 None None
*

Allele frequency, from the Allele*frequencies database.

**

Populations of great concern, defined as populations where 30% or more of the population has an expected phenotype of reduced protection by the vaccine due to having two alleles of concern for a single HLA locus, assuming Hardy-Weinberg equilibrium. Alleles of concern are defined as alleles predicted to bind four or fewer vaccine epitopes.