Table 2. Populations of moderate and great concern for Ag85B-TB10.4.

Gene	Population of concern	Allele ofconcern 1	f*	Allele ofconcern 2	f*	Allele ofconcern 3	f*	Phenotype Frequency
HLA–A	Bangladesh Dhaka Bangalee	A*3301	0.170	A*1101	0.156			0.106
	China Yunnan Province Bulang	A*1101	0.543					0.295
	China Yunnan Province Hani pop 2**	A*1101	0.613					0.376
	China Yunnan Province Wa**	A*1101	0.584	A*3303	0.160			0.554
	India Kerala Hindu Pulaya**	A*1101	0.531	A*0301	0.063	A*3301	0.063	0.432
	India New Delhi	A*1101	0.235	A*0301	0.098			0.111
	India Tamil Nadu Nadar	A*0301	0.205	A*3101	0.189			0.155
	Indonesia Java Western	A*1101	0.164	A*3303	0.162			0.106
	Indonesia Sudanese and Javanese	A*3303	0.169	A*1101	0.164			0.111
	Pakistan Baloch	A*1101	0.222	A*3303	0.127			0.122
	Pakistan Brahui	A*1101	0.252	A*3201	0.092			0.118
	Pakistan Burusho	A*3303	0.179	A*0301	0.130	A*1101	0.125	0.188
HLA–B	None	None						–
HLA–C	None	None						–
HLA-DRB1	None	None						–

^*Allele frequency, from the Allele*frequencies database.

^**Populations of great concern, defined as populations where 30% or more of the population has an expected phenotype of reduced protection by the vaccine due to having two alleles of concern for a single HLA locus, assuming Hardy-Weinberg equilibrium. Alleles of concern are defined as alleles predicted to bind four or fewer vaccine epitopes.