Figure 3. Schematic representation of the regulatory model for the proposed Coro1A-mediated translocation and activation of Rac1 reviewed here. The first stimulus triggering the first burst of Rac1 activity via a Coro1A-independent route is shown on the left in gray color and thin lanes. The Coro1A-based relay mechanism involved in the subsequent amplification of Rac1 signals is shown with thicker lanes. L, ligand; X, a putative Rac1 GEF factor associated to ArhGEF7. Phosphorylated residues are shown as yellow lollipops. See further details in the main text of this work.