Figure 1. Mean fold change in methylation between tumor and normal for 47 matched tissue pairs and all 1413 autosomal CpGs by chromosome. Positive fold change values indicate increased methylation in tumor relative to normal tissue and negative fold change values indicate decreased methylation in tumor relative to normal tissue. Horizontal dotted lines indicate 2-fold and 5-fold changes in mean methylation between tumor and normal lung. Genes with CpG loci chosen for replication in independent populations (HOXA9, SOX1, DDR1) are shown.