Table 1.
Clinical characteristics of the PSC patients included in the study.
| Genome-wide analysis | Replication analysis | ||||
|---|---|---|---|---|---|
| Scandinavian | German | Scandinavian | Central European | United States | |
| Number of PSC patients | 332 | 383 | 289 | 561 | 371 |
| Median age at diagnosis (range) | 34 (10–76) | 32 (9–76) | 37 (12–74) | 35 (2–81) | 41 (8–77) |
| Male patients (%) | 241 (73%) | 259 (69%) | 199 (70%) | 354 (64%) | 239 (64%) |
| IBD data available for (n) patients | 331 | 364 | 249 | 544 | 329 |
| IBD (%) | 260 (79%) | 245 (67%) | 196 (79%) | 347 (64%) | 262 (80%) |
| IBD subtype | |||||
| Ulcerative Colitis (%) | 64% | 51% | 66% | 47% | 66% |
| Crohn’s disease (%) | 10% | 10% | 8% | 13% | 8% |
| IBD unclassified (%) | 4% | 7% | 5% | 4% | 6% |
| CCA data available for (n) patients | 330 | 375 | 243 | 461 | 329 |
| CCA diagnosed (%) | 35 (11%) | 10 (3%) | 27 (11%) | 28 (6.1%) | 27 (8%) |
Clinical characteristics of the patients included in the study stratified according to study panel in the genome-wide analysis or the replication analysis.
IBD, inflammatory bowel disease; CCA, cholangiocarcinoma