Skip to main content
. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Thorac Oncol. 2012 Aug;7(8):1211–1217. doi: 10.1097/JTO.0b013e318257cc89

Figure 4.

Figure 4

A, MK-8033 reduces p-c-Met levels in A549 cells after radiation. A single dose of radiation did not affect the expression of phosphorylated (activated) c-Met, but fractionated radiation (i.e., two doses) did. This increase was attenuated by the addition of MK-8033 (10μM, 2 hours after first radiation) between the two radiation doses. B and C, addition of MK-8033 enhances the levels of γ-H2Ax in A549 cells for upto 6 hours compared to double irradiation and MK-8033 treatment alone suggesting decrease in DNA repair.