. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Biochimie. 2012 Mar 14;94(10):2180–2189. doi: 10.1016/j.biochi.2012.03.006

Table 1.

A tabular summary of the evidence supporting a role for systemic leptin and adiponectin in asthma in humans

		Males		Females
		Population- based studies	Clinic/hospital based studies	Population- based studies	Clinic/hospital based studies
SYSTEMIC LEPTIN-ASTHMA ASSOCIATION
Asthma prevalence	Adults	↔	↔	↑/↔	↔
Asthma prevalence	Children	↔	↑ (prepubertal)	↔	↑ (peripubertal)
Asthma severity	Adults	–	↔	–	↔
Asthma severity	Children	–	↑ (prepubertal)	–	↑ (peri- & postpubertal)
SYSTEMIC ADIPONECTIN-ASTHMA ASSOCIATION
Asthma prevalence	Adults	↑/↓/↔	↔	↓/↔	↔
Asthma prevalence	Children	↔	↔	↔	↓ (peripubertal)
Asthma severity	Adults	↑	↔	↔	↔
Asthma severity	Children	–	↓ (pre- & peripubertal)	–	↔

Key: ↑ means increased effect; ↓ means decreased effect; ↔ means no effect; – means no evidence is currently available.