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The previously proposed mechanism for the reaction of proteasome with EPX. Nucleophilic attack by Thr1-Oγ on EPX results in hemiacetal formation, followed by subsequent cyclization of Thr1-Nz onto the epoxide, resulting in formation of the morpholino adduct. Candidate residues for H-B and B− are the Thr1 amino terminus, a bound water molecule, and invariant Ser130.
